This review summarizes the current knowledge on biological age biomarkers, factors influencing biological aging, and antiaging interventions, with a focus on vascular aspects of the aging process and its cardiovascular disease related manifestations.Īntiaging therapy biological age biological age biomarkers chronological age vascular disease.Ĭopyright © 2020 The Authors. However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. Instead of benchmarking chronological age, my lab is invested in measuring biological age. I am a scientist interested in redefining age. Studies in experimental models and humans have identified 9 highly interconnected hallmark processes driving mammalian aging. This is because there is a difference between your chronological age, or the number of years you’ve been alive, and your biological age your physical and functional ability. My grandmother, who lived to be 83 but was bedridden and could not remember who I was for the. In a progressively aging population, it is essential to develop early-life biomarkers that efficiently identify individuals who are at high risk of developing accelerated vascular damage, with the ultimate goal of improving primary prevention and reducing the health care and socioeconomic impact of age-related cardiovascular disease. Rapid agers experience a faster rate of functional deterioration relative to their chronological age. Electronic address: is the main risk factor for vascular disease and ensuing cardiovascular and cerebrovascular events, the leading causes of death worldwide. 4 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York. Wiener Cardiovascular Institute/Marie-Josée and Henry R. ![]() 3 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain The Zena and Michael A.2 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.1 Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.
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